Company Timeline

Busaburo Otsuka founds Otsuka Seiyaku Kogyo-bu (Otsuka Pharmaceutical)

Production of magnesium carbonate (listed in the Japanese Pharmacopoeia) from the bittern called “Nigari” begun

Production of potassium bromide (listed in the Japanese Pharmacopoeia) begun and a series of new IV solution products decided to start

Otsuka Pharmaceutical renamed Otsuka Pharmaceutical Factory

Licenses obtained to manufacture the following injection solutions: calcium chloride injection, Ringer’s solution, etc.

Production of pharmaceutical products including various intravenous solutions begun

Masahito Otsuka succeeds Busaburo Otsuka as company owner

License obtained to manufacture the glucose injection

MEYLON Injection launched—a 7% sodium bicarbonate IV injection

Glass vial for IV solutions launched

Hydrazide Otsuka launched - an antitubercular drug

Oronine Ointment launched - Otsuka Group's first over-the-counter product

Saralin Tablets launched - a laxative product

Amino acid supplements for nutritional deficiencies launched: PAN-AMIN, an essential amino acid injection, and PAN-AMIN S, a hypertonic injection of essential amino acids

KN solution series (electrolyte solution) launched

LOW MOLECULAR DEXTRAN D INJECTION launched—a circulatory improvement and extracorporeal perfusion solution

Lactec Injection launched - an electrolyte solution (lactated Ringer's solution)

Production of Japan's first plastic bottle for IV solutions begun

Otsuka Pharmaceutical Factory becomes Otsuka Pharmaceutical Factory, Inc.

Masahito Otsuka appointed President

Oronine H Ointment launched - a product for treating minor skin conditions and injuries, containing chlorhexidine gluconate, which has excellent antiseptic properties

MARTOS Injection 10% launched—a disaccharide IV injection

Japan’s first injection solution in plastic ampule launched

Yoshimitsu Otsuka appointed President

Kushiro Factory established

Arab Otsuka Pharmaceutical established in Egypt (currently Egypt Otsuka Pharmaceutical Co., S.A.E.)

Injection in twist-off type plastic ampule launched—a product that can be opened by twisting the tip

POTACOL R Injection launched—a lactated Ringer’s solution containing 5% maltose

PLAS-AMINO Injection launched—an injection with glucose and amino acids

AMINOLEBAN IV Injection launched—an amino acid injection for treatment of hepatic encephalopathy

Normal saline injection and distilled water for dissolving drugs launched in 100-mL piggy bottles

Otsuka Techno Corporation established

TRIPAREN No. 1/No. 2 Injection launched—a TPN electrolyte solution containing complex carbohydrates (GFX)

Akihiko Otsuka appointed President

AMIPAREN Injection launched—a 10% amino acid solution

Otsuka MV Injection launched - Multivitamins for Total Parenteral Nutrition

Matsushige Factory established

OTSUKA NORMAL SALINE TN and OTSUKA GLUCOSE INJECTION 5% TN launched—a diluent with transfer needle

Urepearl Plus Lotion launched—a medicine for the treatment of dry skin

Twinline Liquid for Enteral Use launched - an elemental diet preparation

AMINOTRIPA No. 1/No. 2 Injection launched—an amino acid, carbohydrate, and electrolyte solution for TPN

TRIFLUID Injection launched—an electrolyte maintenance solution with 10.5% complex carbohydrates

Yoshimitsu Otsuka appointed President

Otsuka multi-chamber bag system and world’s first antibiotic kit product using it obtained manufacturing approval

Cefazolin Sodium Injection 1g Bag Otsuka launched - a cephalosporin antibiotic for intravenous administration

KIDMIN Injection launched—a 7.2% amino acid injection for renal failure

AMINOFLUID Injection launched—an amino acid, carbohydrate, and electrolyte solution

Urepearl Plus Cream launched―a medicine for the treatment of dry skin

Kyoichi Komatsu appointed President

New Saralin launched—a laxative newly formulated with all natural ingredients

RACOL Liquid for Enteral Use launched—a low residual diet preparation

Physio 140 Injection launched - an electrolyte solution (a 1% glucose and acetated Ringer's solution)

Toyama Factory established

Intralipos Injection 10%/20% launched - an intravenous fat emulsion

OS-1 launched—an oral rehydration ion beverage based on the approach to oral rehydration therapy proposed by the WHO

EN Otsuka Pharmaceutical Co., Ltd. established

MIXID L/H Injection launched—a TPN formulation with fat that contains amino acids, glucose, and electrolytes

Otsuka OPV established (currently Otsuka Pharmaceutical Vietnam Joint Stock Company)

OS-1 Jelly launched—an oral rehydration ion beverage suitable for persons with difficulty chewing or swallowing

GFO launched - a powdered drink mix containing glutamine, fiber, and oligosaccharides

J.O. Pharma Co., Ltd. established

NEOPAREN No. 1/No. 2 Injection launched—a formulation containing glucose, electrolytes, amino acids, and multiple vitamins for TPN

OTSUKA NORMAL SALINE 2-PORT and OTSUKA GLUCOSE INJECTION 5% 2-PORT launched— a diluent with transfer needle

Ichiro Otsuka appointed President

Oral rehydration solution OS-1 approved as food for persons with medical conditions (individually evaluated type); categorized as food for special dietary use by the Ministry of Health, Labour and Welfare

Renewal design of plastic infusion bag which considers clarity and distinguishability to prevent a medication mix-up

ENGELEAD Apple Jelly launched—a food for persons with difficulty swallowing, suitable for managing normal oral intake

BFLUID Injection launched—a carbohydrate, electrolyte, and amino acid solution with vitamin B₁

Heparin Na Lock 10 and 100 units/mL SYRINGE OTSUKA launched—an anticoagulant prefilled syringe product

NORMAL SALINE SYRINGE OTSUKA launched—a prefilled syringe product

Oral rehydration solution OS-1 Jelly approved as food for persons with medical conditions (individually evaluated type); categorized as food for special dietary use by the Ministry of Health, Labour and Welfare

HINE Bag launched—a concentrated liquid diet that takes into account nutritional management for persons with low energy needs

Suzhou Otsuka Pharmaceutical Co., Ltd. established

HINE Jelly launched—a concentrated liquid diet given jelly form with agar

ARTCEREB irrigation and perfusion solution for cerebrospinal surgery launched

Otsuka Holdings Co., Ltd. established

Urepearl Plus Lotion 10 launched—a medicine for the treatment of dry skin with improved formulation, effect and use sensation

Innerpower, beverage (jelly), launched

Oral rehydration solution OS-1 Powder launched—a powder type that is convenient for carrying around

ELNEOPA No. 1/No. 2 Injection launched—a TPN formulation containing glucose, electrolytes, amino acids, multiple vitamins, and trace elements

HINE Jelly Aqua launched—a concentrated liquid diet with added water

BICANATE Injection launched—a bicarbonated Ringer’s solution

Otsuka Holdings Co., Ltd. listed on the First Section of the Tokyo Stock Exchange

Sodium Phosphate Corrective Injection 0.5 mmol/mL launched—a corrective electrolyte solution

RACOL-NF Liquid for Enteral Use, a low residual diet preparation (for feeding tube and oral administration), and Twinline-NF Liquid for Enteral Use, an elemental diet preparation, launched

Diatranz Otsuka Limited established in New Zealand

Oral rehydration solution OS-1 Powder approved as food for persons with medical conditions (individually evaluated type) categorized as food for special dietary use by the Consumer Affairs Agency

Voluven 6% Solution for Infusion launched - a plasma substitute

Capital participation in Claris Otsuka Private Limited (currently Otsuka Pharmaceutical India Private Limited)

ENGELEAD Apple Jelly and ENGELEAD Grape Jelly approved as a food for special dietary use, food for persons who have difficulty swallowing (approval standardⅠ) by the Consumer Affairs Agency

HINE E-Gel launched—a concentrated liquid diet that changes state from liquid to gel form in reaction with stomach acids

Povidone-iodine Solution 10% Antiseptic Applicator Otsuka 10 mL/25 mL launched—an external-use antiseptic

RACOL-NF SemiSolid for Enteral Use launched—an enteral nutrient solution

Shinichi Ogasawara appointed President

Acquired a local pharmaceutical company in Egypt as a subsidiary (currently Otsuka Al-Obour Pharmaceutical Egypt S.A.E.)

PROCESS LEAD launched—a chew and swallow managing food that takes into account physical properties after chewing

Lilium Otsuka Co., Ltd. established

Olanedine Antiseptic Solution 1.5% and Olanedine Solution 1.5% Antiseptic Applicator launched—an external-use antiseptic

Lilium α-200 launched - an ultrasound bladder imaging device

ELNEOPA-NF No. 1/No. 2 Injection launched—a TPN formulation containing glucose, electrolytes, amino acids, multiple vitamins, and trace elements

HINE Jelly, and HINE Jelly AQUA—a concentrated liquid diet, approved as comprehensive nutritional food for patients [zinc adjustment] categorized as food for special dietary use by the Consumer Affairs Agency

Rebamipide tablets 100mg Otsuka launched - an anti-gastritis and anti-gastric ulcer agent

HINEX REHADAYS launched—a beverage to support exercise and rehabilitation

ENORAS Liquid for Enteral Use (for feeding tube and oral administration) launched

Cellstor-S cell suspension and preservation solution and Cellstor-W cell wash and preservation solution launched

HINE E-Gel LC launched—a concentrated liquid diet product

Oral care gel (medicated toothpaste) HINORA (quasi-drug) and oral moisture gel HINORA Moisture Gel (oral cosmetic) launched

Oral rehydration solution OS-1 series approved for new labeling including “prevention of deterioration of or recovery from dehydration” and “heatstroke with dehydration” as individually evaluated food for persons with medical conditions, categorized as food for special dietary use by the Consumer Affairs Agency

VISCOCLEAR launched―gel to secure the visual field that is used for the endoscope for natural opening

ENEFLUID Injection launched―an amino acid, carbohydrate, electrolyte, fat, and water-soluble vitamin injection

HINEX E-Gel and HINEX E-Gel LC launched― concentrated liquid diet products, as new products with changed names and some compositions

Otsuka Gypto Pharmaceutical Egypt S.A.E. established in Egypt

Actreen launched—an intermittent urological catheter

Tolvaptan OD tablets 7.5/15 mg Otsuka launched―a vasopressin V₂-receptor antagonist

Lilium IP200 launched—an ultrasound bladder imaging device

Pokenyu (Pocket Nutrition) service begun—a cloud service that helps professionals involved in home medical care identify and solve dietary and nutritional issues for home medical care patients

OS-1 Apple Flavor added to the Oral Rehydration Solution OS-1 series

OT-Balloon Catheter launched—an intermittent urological catheter

Lilium one launched— a medical device that measures urine volume in the bladder specialized for single measurement

HINEX RENUTE launched—a concentrated liquid diet food that effectively supplies protein and energy in the initial stage of nutrition resumption

Tumguide LED Light Source and Tumguide Fiber launched—medical devices that configure Tumguide, a device for checking the position of the nasogastric tube tip

Shuichi Takagi appointed President

Otsuka Clinical Solutions, Inc. established

HINEX Jelly launched—a concentrated liquid diet product with improved compositions and physical properties