We are a leading company of IV solutions in Japan. Our history is the very history of the development of Japanese IV products. We are committed to being the best partner of patients and healthcare professionals in the field of clinical nutrition.
Busaburo Otsuka founds Otsuka Seiyaku Kogyo-bu (Otsuka Pharmaceutical)
Production of pharmaceutical products including various intravenous solutions begun
Glass vial for IV solutions launched
Oronine Ointment launched - Otsuka Group's first over-the-counter product
Production of Japan's first plastic bottle for IV solutions begun
MARTOS Injection 10% launched - a disaccharide IV injection
– From developing glucose solutions to developing peripheral parenteral nutrition solutions –See details ▶
Injection in twist-off type plastic ampule launched—a product that can be opened by twisting the tip
PLAS-AMINO Injection launched—an injection with glucose and amino acids
Normal saline injection and distilled water for dissolving drugs launched in 100-mL piggy bottles
TRIPAREN No. 1/No. 2 Injection launched—a TPN electrolyte solution containing complex carbohydrates (GFX)
– Development of TPN solutions and enteral nutrition products –See details ▶
AMIPAREN Injection launched—a 10% amino acid solution
AMINOTRIPA No. 1/No. 2 Injection launched—an amino acid, carbohydrate, and electrolyte solution for TPN
AMINOFLUID Injection launched—an amino acid, carbohydrate, and electrolyte solution
RACOL Liquid for Enteral Use launched—a low residual diet preparation
OS-1 launched—Japan’s first oral rehydration ion beverage based on the approach to oral rehydration therapy proposed by the WHO
NEOPAREN No. 1/No. 2 Injection launched—a formulation containing glucose, electrolytes, amino acids, and multiple vitamins for TPN
BFLUID Injection launched—a carbohydrate, electrolyte, and amino acid solution with vitamin B₁
NORMAL SALINE SYRINGE OTSUKA launched—an anticoagulant prefilled syringe product
ELNEOPA No. 1/No. 2 Injection launched—a TPN formulation containing glucose, electrolytes, amino acids, multiple vitamins, and trace elements
Olanedine Antiseptic Solution 1.5% and Olanedine Solution 1.5% Antiseptic Applicator launched—an external-use antiseptic
ENORAS Liquid for Enteral Use (for feeding tube and oral administration) launched
ENEFLUID Injection launched―an amino acid, carbohydrate, electrolyte, fat, and water-soluble vitamin injection
The Otsuka Group began with the establishment of Otsuka Seiyaku Kogyo-bu (Otsuka Pharmaceutical) in Naruto City, Tokushima Prefecture, in 1921 by the founder Busaburo Otsuka (1891-1970). At that time, it was a chemical raw material manufacturer that produced magnesium carbonate (listed in the Japanese Pharmacopoeia) from salt field residues.
The Otsuka Memorial House (first office and laboratory)
In 1946, we started manufacturing intravenous infusion solutions, entered the pharmaceutical field, and in 1951, we launched IV solutions in glass vials. Subsequently, as the demand for IV solutions expanded, we developed a variety of IV solutions, particularly in 1968, we launched Japan’s first plastic container for IV solutions and established a position in the IV industry.
Same type of infusion solution as that at the start of IV solution business (The photo is a product from 1948-1950s.)
Glass vial for IV solutions
Japan’s first plastic bottle for IV solutions
In addition to the clinical nutrition field, Otsuka Pharmaceutical Factory has been developing a variety of products. In 1953, Oronine Ointment was launched as the first over-the-counter drug by the Otsuka Group.
Enamel signboard featuring Chieko Naniwa
Note: Product photos are generally those at the time of launch. Ethical drugs and other products are listed under the brand name, not under the product name.